- Project Type
Technology Implementation and Support
Citrus Heights, CA
Technology support for CIS, FIS, CMMS, GIS and mobile computing
IT management & planning services
Ms. Pam Peters
6230 Sylvan Road
Citrus Heights, CA 95610
“Jeff has been supporting the District for a long time. We continue to use his knowledge of the Water industry and our applications to improve our operations. He is an integral part of our technology team”
- Bob Churchill, GM, CHWD
Proscar 5 mg
Medical Disclaimer Next Interactions Add to proscar My Med List More about Proscar proscar (finasteride) Consumer resources Professional resources Other brands: Propecia Related treatment guides. Table 5: All Treatment Failures in proscar pless Event Patients Placebo N1503 Finasteride N1513 Relative Risk 95 Calue All Treatment Failures.1.2.68 (0.57.79).001 Surgical Interventions for BPH.1.6.45 (0.32.63).001 Acute Urinary Retention. In man, the proscar 5-reduced steroid metabolites in proscar blood and proscar urine are decreased after administration proscar of proscar finasteride. The fetal proscar effects proscar of proscar maternal finasteride exposure proscar during the proscar period of embryonic and fetal development were evaluated in proscar the rhesus monkey (gestation days 20-100 in proscar a species and development period more predictive of specific proscar effects in proscar humans than the studies in rats and rabbits. Proscar was further evaluated in the Proscar Long-Term Efficacy and Safety Study (pless a double-blind, randomized, placebo-controlled, 4-year, multicenter study. Because of the ability of Type II 5-reductase inhibitors to inhibit the conversion of testosterone to 5-dihydrotestosterone (DHT finasteride may proscar cause abnormalities of the external genitalia of a male fetus of a pregnant woman who receives proscar finasteride. This proscar decrease was associated with an increase proscar in fecal excretion of metabolites. 5-reductase inhibitors may increase the risk of development of high-grade prostate cancer. In some men, BPH can lead to serious problems, including urinary tract infections, a sudden inability to pass urine (acute urinary retention as proscar well as the need for surgery. Summary of Clinical Studies The data from these studies, showing improvement in BPH-related symptoms, reduction in treatment failure (BPH-related urological events increased maximum urinary flow rates, and decreasing prostate volume, suggest that Proscar arrests the disease process of BPH in men with an enlarged prostate. Excretion In healthy young subjects proscar (n15 mean proscar plasma clearance of finasteride was 165 mL/min (range, 70-279 mL/min) and mean elimination half-life in plasma was 6 hours proscar (range, 3-16 hours). Finasteride is a competitive and specific inhibitor of Type II 5-reductase with which it slowly forms a stable enzyme complex. Any increase in follow-up PSA proscar levels from their lowest point may signal the presence of prostate cancer proscar and should be evaluated, even if the test results are still within the normal range. For more information call. Your doctor may continue checking for prostate cancer while you proscar take Proscar. Because Proscar decreases PSA levels, you should tell your doctor(s) that you are taking Proscar. The most common side effects of Proscar include: trouble getting or keeping an erection (impotence) decrease in sex drive decreased volume of ejaculate proscar ejaculation disorders enlarged or painful breast. The mean terminal half-life of finasteride in subjects 70 years of age was approximately 8 hours (range, 6-15 hours; n12 compared with 6 hours (range, 4-12 hours; n12) in subjects 45-60 years of age. The mean prostate volume as measured by transrectal ultrasound was.3 mL (20.1 mL). In sexually mature male rats treated with 61 times proscar side effects the human exposure (80 mg/kg/day there were no significant effects on proscar fertility after 6 or 12 weeks of treatment; however, when treatment was continued for up to 24 or 30 weeks, there was. Clinical pharmacology, mechanism Of Action, the development and enlargement of the prostate gland is dependent on the potent androgen, 5- dihydrotestosterone dHT ). However, finasteride has been well tolerated in BPH patients with normal renal function proscar receiving up to 80 mg/day for 12 weeks, where exposure of these patients to metabolites would presumably be much greater. Finasteride is not indicated for use in pediatric patients see warnings AND precautions, Use In Specific Populations. How should I take Proscar? Intravenous administration of finasteride to pregnant monkeys at doses as high as 800 ng/day (estimated maximal blood concentration.86 ng/mL or about 143 times the highest estimated exposure of pregnant women to finasteride from semen of men taking 5 mg/day). These doses produced respective proscar systemic exposure in rats of 111 and 274 times those observed in man proscar receiving the recommended human dose of 5 mg/day. Figure 1: Symptom Score in pless Results seen in earlier studies were comparable to those seen in pless. Proscar is a Type II 5-reductase inhibitor that prevents conversion of testosterone to 5-dihydrotestosterone (DHT a hormone necessary for normal development of male genitalia. Treatment with Proscar, doxazosin proscar or the combination of Proscar with doxazosin, reduced the mean symptom score from baseline at year. At maternal doses of oral finasteride approximately.1 to 86 times the maximum recommended human dose (mrhd) of 5 mg/day (based on AUC at animal doses.1 to 100 mg/kg/day) there was a dose-dependent increase in hypospadias. During the 4-year, placebo-controlled pless study that enrolled 3040 men, there were 2 cases of breast cancer in placebo-treated men but no cases in men treated with finasteride. Store Proscar tablets in a dry place at room temperature. Safety and effectiveness in pediatric patients have not been established. In healthy volunteers, treatment with proscar did not alter the response proscar of LH and FSH to gonadotropin -releasing hormone indicating that the hypothalamic- pituitary -testicular axis was not affected. As a result, mean AUC(0-24 hr) after 17 days of dosing was 15 higher in subjects 70 years of age than in subjects 45-60 years of age (p0.02). The most frequently proscar reported adverse reactions were related to sexual function. Approximately 90 of circulating finasteride is bound to plasma proteins. Checking for prostate cancer. Effect on Prostate Volume In pless, prostate volume was assessed yearly by magnetic resonance imaging (MRI) in a subset of patients. 1883 patients completed the 4-year study (1000 in the finasteride group, 883 in the placebo group). Only those who tolerated the 4 or 8 mg dose level were kept on doxazosin (or its placebo) proscar in the study. Geriatric No dosage adjustment is necessary in the elderly. Do not store in the bathroom. Table 5: All Treatment Failures in pless Patients Event Placebo N1503 Finasteride N1513 Relative Risk 95 Calue All Treatment Failures.1.2.68 (0.57.79).001 Surgical Interventions for BPH.1.6.45 (0.32.63).001 Acute Urinary Retention. Additional Instructions Physicians should inform patients that the volume of ejaculate may be decreased in some patients during treatment with Proscar. Patients were evaluated annually with PSA and digital rectal proscar exams. In confirmation of the relevance of the rhesus model for human fetal development, oral administration of a dose of finasteride (2 mg/kg/day or approximately 18,000 times the highest estimated blood levels of finasteride from semen of men taking 5 mg/day) to pregnant monkeys. In patients with BPH treated with finasteride (1-100 mg/day) for 7-10 days prior to prostatectomy, an approximate 80 lower DHT content was measured in prostatic tissue removed at surgery, compared to placebo; testosterone tissue concentration was increased up to 10 proscar times over pretreatment levels, relative to placebo. Finasteride is The empirical formula of finasteride is C23H36N2O2 and its molecular weight is 372.55. Your doctor may have done a blood test called PSA for the screening of prostate cancer. Call your doctor for medical advice about side effects. Also, read it each time you renew your prescription, just in case anything has changed. Storage, store US product at room temperature below 86 degrees F (30 degrees C) away from light and moisture in a tightly closed container. Depression decrease in sex drive that continued after stopping the medication in rare cases, male breast cancer has been reported. Physicians should instruct their patients to promptly report any changes in their breasts such as lumps, proscar pain or nipple discharge. Overdosage Patients have received single doses of Proscar up to 400 mg and multiple doses of Proscar up to 80 mg/day for three months without adverse effects. Following an oral dose of 14C-finasteride in man (n6 a mean of 39 (range, 32-46) of the dose was excreted in the urine in the form of metabolites; 57 (range, 51-64) was excreted in the feces. Although steady state was not reached in this study, mean trough plasma concentration in another study in patients with BPH (mean age, 65 years) receiving 5 mg/day was.4 ng/mL (range,.1-13.3 ng/mL; n22) after over a year of dosing. For more information, talk to your doctor. For interpretation of serial PSAs in men taking Proscar, a new PSA baseline should be established at least six months after starting treatment and PSA monitored periodically thereafter. The mean patient age at randomization was.6 years (7.3 years). Except for the associated urogenital defects present at birth, no other clinical abnormalities related to Type II 5-reductase deficiency have been observed in these individuals. Effect on Acute Urinary Retention and the Need for Surgery In pless, efficacy was also proscar proscar assessed by evaluating treatment failures. In man, a single 5-mg oral dose of proscar produces a rapid reduction in serum proscar DHT concentration, with the maximum effect observed 8 hours after the first dose. However, impotence and decreased libido may occur in patients treated with Proscar see Adverse Reactions (6.1). Lowering DHT leads to shrinkage of the enlarged prostate gland in most men. Compounds that have been tested in man have included antipyrine, digoxin, propranolol, theophylline, and warfarin and no clinically meaningful interactions were found. No developmental abnormalities were observed in the offspring of untreated females mated with finasteride treated male rats that received approximately 61 times the mrhd (based on AUC at animal dose of 80 mg/kg/day). Slightly decreased fertility was observed in male offspring after administration of about 3 times the mrhd (based on AUC at animal dose of 3 mg/kg/day) to female rats during late gestation and lactation. The incidence rates of drug-related adverse experiences reported by 2 of patients in any treatment group in the mtops Study are listed in Table. Its structural formula is: Finasteride is a white crystalline powder with a melting point near 250C. Effect on Semen Characteristics Treatment with Proscar for 24 weeks to evaluate semen parameters in healthy male volunteers revealed no clinically meaningful effects on sperm concentration, mobility, morphology,. Women who are or may potentially be pregnant must not use Proscar. (See Table.) Table 6: Count and Percent Incidence of Primary Outcome Events by Treatment Group in mtops Treatment Group Placebo Doxazosin Finasteride Combination Total N737 proscar N756 N768 N786 N3047 Event N N N N N AUA. Proscar may increase the chance of a more serious form of prostate cancer. Do Not Take Proscar if you are: a woman who is pregnant or may potentially be pregnant. Revised: 09/2013 usppi-mk0906-5t-1309r011 principal display panel - 5 mg Bottle Label NDC Proscar (finasteride) Tablets 5 mg warning: Proscar (finasteride) should not be used by women or children. Proscar may also cause decreases in serum PSA in the presence of prostate cancer. In healthy volunteers, treatment with Proscar did not alter the response of LH and FSH to gonadotropin-releasing hormone indicating that the axis was not affected. (See Figure.) proscar A statistically significant improvement in symptom score was evident at 1 year in patients treated with Proscar vs placebo (2.3.6 and this improvement continued through Year. It is freely soluble in chloroform and in lower alcohol solvents, but is practically insoluble in water. Combination with Alpha-Blocker, proscar administered in combination with the alpha-blocker doxazosin is indicated to reduce the risk of symptomatic progression of BPH (a confirmed 4 point increase in American Urological Association (AUA) symptom score). Patients with large residual proscar urinary volume and/or severely diminished urinary flow should be carefully monitored for obstructive uropathy. Thus, based on a 5-mL ejaculate volume, the amount of finasteride in semen was estimated to be 50- to 100-fold less than the dose of finasteride (5 g) that had no effect on circulating DHT levels in men see also Use In Specific Populations. Mean trough concentrations after 17 days of dosing were.2 ng/mL (range,.4-9.8 ng/mL) and.1 ng/mL (range,.8-19.7 ng/mL respectively, in the two age groups. Figure 5: Cumulative Incidence of a 4 -Point Rise in AUA Symptom Score by Treatment Group Treatment with proscar, doxazosin or the combination of proscar with doxazosin, reduced the mean symptom score from baseline at year. Caution should be exercised in the administration of proscar in those patients with liver function abnormalities, as finasteride is metabolized extensively in the liver. Canada residents can call a provincial poison control center. The individual adverse effects which occurred more frequently in the combination group compared to either drug alone were: asthenia, postural hypotension, peripheral edema, dizziness, decreased libido, rhinitis, abnormal ejaculation, impotence and abnormal sexual function (see Table 2). Follow your doctor's instructions for examining your breasts and testicles, and report any lumps right away. (See Figure.) A statistically significant improvement in symptom score was evident at 1 year in patients treated with proscar vs placebo (2.3.6 and this improvement continued through Year. In patients receiving Proscar 5 mg/day, increases of about 10 were observed in luteinizing hormone (LH) and follicle-stimulating hormone (FSH but levels remained within the normal range. Monotherapy, the recommended dose of Proscar is one tablet (5 mg) taken once a day see. If a woman who is pregnant with a male baby proscar absorbs the active ingredient in Proscar after oral use or through the skin, it may cause the male baby to be born with abnormalities of the sex organs. In mtops, the risk of developing acute urinary retention was reduced by 67 in patients treated with proscar compared to patients treated with placebo (0.8 for proscar and.4 for placebo). Finasteride has been shown to cross the blood brain barrier but does not appear to distribute preferentially to the CSF. Proscar may be prescribed along with another medicine, an alpha-blocker called doxazosin, to help you better manage your BPH symptoms. No evidence of male external genital malformations or other abnormalities were observed in rabbit fetuses exposed to finasteride during the period of major organogenesis (gestation days 6-18) at maternal oral doses up to 100 mg/kg/day, (finasteride exposure levels were not measured in rabbits). These patients may not be candidates for finasteride therapy. If a woman who is pregnant comes into contact with the active ingredient in Proscar, a doctor should be consulted. Turnover from this complex proscar is extremely slow (t 30 days). The mean duration of BPH symptoms was.7 years (4.6 years). (001317601) Merck proscar side effects Sharp Dohme Corp. Active ingredients: finasteride Inactive ingredients: hydrous lactose, microcrystalline cellulose, proscar pregelatinized starch, sodium starch glycolate, hydroxypropyl cellulose LF, hydroxypropyl methylcellulose, titanium dioxide, magnesium stearate, talc, docusate sodium, proscar FD C proscar Blue 2 aluminum lake and yellow iron oxide. This decrease does not appear to interfere with normal sexual function. If a woman who is pregnant or may potentially be pregnant comes in contact with crushed or broken Proscar tablets, the contact area should be washed immediately with soap and water see Contraindications (4), Warnings and Precautions (5.3), Use in Specific. This decrease is predictable over the entire range of PSA values in patients with symptomatic BPH, although it may vary in individuals. Dosage Forms and Strengths 5-mg blue, modified apple-shaped, film-coated proscar tablets, with the code MSD 72 on one side and Proscar on the other. Exposure of Women Risk to Male Fetus Physicians should inform patients that women who are pregnant or may potentially be pregnant should not handle crushed or broken Proscar tablets because of the possibility of absorption of finasteride and the. The primary endpoint was a composite measure of the first occurrence of any of the following five outcomes: a 4 point confirmed increase from baseline in symptom score, acute urinary retention, BPH-related renal insufficiency (creatinine rise recurrent urinary tract infections or urosepsis, or incontinence. Proscar (finasteride) tablets for oral administration are film-coated tablets that contain 5 mg of finasteride and the following inactive ingredients: hydrous lactose, microcrystalline cellulose, pregelatinized starch, sodium starch glycolate, hydroxypropyl cellulose LF, hydroxypropyl methylcellulose, titanium dioxide, magnesium stearate, talc. male infertility and/or poor seminal quality were reported rarely in men taking Proscar for the treatment of BPH. These outcomes are similar to those reported in male infants with genetic 5-reductase deficiency. Finasteride use is contraindicated in women when they are or may potentially be pregnant. It has been prescribed only for you. Finasteride does not appear to affect the cytochrome P450-linked drug metabolizing enzyme system. Pharmacokinetics Absorption In a study of 15 healthy young subjects, the mean bioavailability of finasteride 5-mg tablets was 63 (range 34-108 based on the ratio of area under the curve (AUC) relative to an intravenous (IV) reference dose. Combination therapy resulted in a significant reduction in the risk of the primary endpoint compared to treatment with Proscar alone (49;.001) or doxazosin alone (46;.001). Mean maximum urinary flow rate was.5 mL/sec (2.6 mL/sec). Table 3: Mean (SD) Pharmacokinetic Parameters in Healthy Young Subjects (n15) Mean ( SD) Bioavailability 63 (34-108 Clearance (mL/min) 165 (55) Volume of Distribution (L) 76 (14) Half-Life (hours).2 (2.1) *Range Pediatric Finasteride pharmacokinetics have not been investigated in patients 18 years of age. Increased Risk of High-Grade Prostate Cancer. Do not share Proscar with anyone else; it was prescribed only for you. Figure 2: Percent of Patients Having Surgery for BPH, Including turp Figure 3: Percent of Patients Developing Acute Urinary Retention (Spontaneous and Precipitated) Effect On Maximum Urinary Flow Rate In the patients in pless who remained. A warning about Proscar and pregnancy: Women who are or may potentially be pregnant must not use Proscar. Protect from light and keep container tightly closed. Allergic to finasteride or any of the ingredients in Proscar.
Important information, proscar should never be taken by a woman or a child. What should I avoid? It is not proscar to be used for medical diagnosis, medical advice or treatment. Finasteride should never be taken by a woman or a child. There proscar may be other drugs that can interact with Proscar Tell your doctor about all medications you proscar use. Before starting treatment, you need to conduct a rectal examination for the uses presence of uses cancer. Are uses there any other precautions or warnings for this medication? These may be signs of male breast cancer. In the earlier 1- year studies, proscar increase in maximum urinary flow rate was comparable proscar to pless and uses was maintained through the first year and throughout an additional 5 years of open uses extension studies. The drug is "Proscar". Take the missed dose as soon as you remember. Some medicines need to be tapered or cannot be stopped immediately because of rebound effects. In many cases, interactions are intended or are managed by close monitoring. Decreased interest in sex decreased volume of ejaculate (i.e., semen) erectile dysfunction (impotence) testicular pain, although most of these side effects listed below don't happen very often, they could proscar lead to serious problems if you do not check with your doctor or seek medical attention. Overview, proscar Tablet is used for, benign proscar prostatic hyperplasia, Androgenetic proscar alopecia, Male pattern hair loss and other conditions. Summary Of Clinical Studies The data from these studies, showing improvement in BPH-related symptoms, reduction in treatment failure (BPH-related urological events increased maximum urinary flow rates, and decreasing prostate volume, proscar suggest that proscar arrests the disease process of BPH in men with an enlarged prostate). Before taking Proscar, tell your doctor if you have ever had an allergic reaction to finasteride, or to a similar medicine called dutasteride (Avodart). In patients treated for three months, prostate volume, which declined by approximately 20, returned to close to baseline value after approximately three months of discontinuation of therapy. Multum information has been compiled for use proscar by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Keep all medicines away from children and pets. If a woman accidentally comes into proscar contact with this medication from a broken or crushed tablet, wash the area with soap and water right away. It is not known with certainty whether finasteride can cause breast cancer, but this possibility cannot be ruled out at this time. The information given above is incomplete, and it should not influence the decision on treatment or its cancellation. Two metabolites, the t-butyl side chain monohydroxylated and monocarboxylic acid metabolites, have been identified that possess no more than 20 of the 5-reductase inhibitory activity of finasteride.
Patients should call a doctor proscar immediately if they develop a new severe pain in the groin). The dose can then be increased to proscar 100mg if 50mg is not strong enough. Metabolism of Prednisone to form prednisolone occurs via the enzyme 11-Beta hydrozysteroid dehydrogenase (hydrogenation of the ketone group at position 11). It is taken by mouth. In some cases, such as for an acute inflammation like an upper respiratory tract infection, the course of prednisone might be short; it's only used for a few days proscar or weeks. This drug works by blocking the hormone angiotensin thereby relaxing blood proscar vessels, causing them to widen. Advise breastfeeding patient to avoid breastfeeding while taking proscar drug. Do not not flush medications down the toilet or pour them into a drain unless instructed to. Uses: Prevention of atherothrombotic events in patients with non-ST-segment elevation acute coronary syndrome (UA, nstemi, proscar those who are to be managed medically, those who are to be managed with coronary revascularization) and proscar stemi. Also was prescribed Metrondiazole (antibiotic) and no relief from that. Deep vein thrombosis (DVT) is a dangerous and sometimes fatal blood clot that occurs deep within the lower leg or thigh. Oral steroids may also be prescribed when your asthma symptoms worsen but you proscar do not require hospitalization. European Medicines Agency and, mHRA, a generic medicine must be 'bioequivalent' to the originator product. If any of these effects persist or worsen, tell your doctor or pharmacist proscar promptly. Left ventricular hypertrophy, diabetic nephropathy, contraindications, none. See also: Side effects (in proscar more detail) What other drugs will proscar affect Plavix? "The efficacy and safety of valsartan compared with placebo in the treatment of patients with essential hypertension." Clin Ther 18 proscar (1996. For children, the dosage is also based on weight. Do not take potassium supplements or salt substitutes containing potassium without talking to your doctor or pharmacist first. Do not double the dose to catch. If you have enteric coated (red or brown) tablets, you can take these with or without food but make sure to swallow them whole. If you think you or someone you know is having a stroke call 911 immediately. The goal of IBD treatment is typically to wean a patient off the steroids, but sometimes it can be difficult. Frye CB, Pettigrew TJ "Angioedema and photosensitive rash induced by valsartan." Pharmacotherapy 18 (1998 866-8. Information last revised October 2013. How the Heart Works, the heart is a very important organ proscar in the body. Polymorphic clopidogrel hydrogenesulphate form Patent 6,429,210 Issued: August 6, 2002 Inventor(s Andr eacute; ; Bousquet Bertrand; Castro Jean; Saint-Germain Assignee(s Sanofi-Synthelabo Novel orthorombic polymorph of clopidogrel hydrogen sulfate or hydrogen sulfate of methyl and a process for its preparation. Our doctors will review your order, issue your prescription and pass it straight to the Superdrug pharmacists to be dispensed. Other ED Medications We offer a range of ED medications. What is bactrim ds tablet used for. No one wants to be put on prednisone but there's no denying that, for many people, it gets results and calms inflammation quickly. Why is DailyMed no longer displaying pill images on the Search Results and Drug Info pages? Amoxil 500 amoxil 500 is Blue Pink, Capsule-shape and has been identified. A short course of 10 mg of prednisone a day may not cause side effects. The following article explains how the consumption of this proscar drug leads to weight gain. 250 mg orally every 6 hours or 500 mg orally every 12 hours for 7 to 14 days. Your doctor may instruct you to stop clopidogrel for 5 to 7 days before surgery. Irons BK, proscar Kumar A "Valsartan-induced angioedema." Ann Pharmacother proscar 37 (2003 1024-7. Related Resources for Plavix Plavix Patient Information is supplied by Cerner Multum, Inc. Precautions, drug Interactions, overdose, notes, missed Dose, storage. To minimize dizziness and lightheadedness, get up slowly when rising from a seated or lying position. If you become pregnant or think you may be pregnant, contact your doctor immediately. HOW TO USE: Read the Patient Information Leaflet if available from your pharmacist before you start taking valsartan and each time you get a refill. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care is drug may also be used to help protect the kidneys from damage due to diabetes. Medical Alert, your condition can cause complications in a medical emergency.
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